Data · collection · 2015
Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note
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Purpose : To assess the impact of Acanthamoeba keratitis (AK) and amniotic membrane transplantation (AMT) in corneal explants on presence of two multifunctional endogenous lectins, i.e. galectins-1 and -7.
Description
Methods
Ten corneal explants from AK patients (five with previous AMT and five controls without this treatment) and seven specimens of disease-free control cornea were processed by indirect fluorescent immunohistochemistry. Results : Immunostaining for both galectins was obtained in the epithelium, stroma and the endothelial layer of all controls, with the strongest positivity in the epithelium. Significantly decreased intensity for galectin-1 was recorded in the epithelium of corneal explants from patients with AK and AMT.
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The signal for galectin-7 was significantly decreased in the epithelium of AK patients and normalized after AMT. Conclusions : AMT has a marked impact on presence of the two galectins in opposite directions, encouraging complete profiling for this family of endogenous effectors.
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Where it is published
- Repository landing page figshare.com/collections/Regulatory_Impact_of_Amniotic_Membrane_Transplanta… ↗
landing page · from DataCite
- Repository landing page figshare.com/collections/Regulatory_Impact_of_Amniotic_Membrane_Transplanta… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2114369 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2114369.v1 ↗
DOI / persistent id · from DataCite
Documentation and papers
- CC-BY creativecommons.org/licenses/by/3.0/us ↗
license · from DataCite
- IsSupplementTo 10.3109/02713683.2015.1061022 doi.org/10.3109/02713683.2015.1061022 ↗
publication · from DataCite
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2114369.v1 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2114369 ↗
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- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2114369.v1 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2114369 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Biological sciences · Biological sciences · Clinical medicine · Clinical medicine · Mathematics · Mathematics
- From keywords
- Biochemistry and cell biology · Genetics · Microbiology
Provenance · 2 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.2114369 | 15 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.c.2114369.v1 | 15 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:mathematics | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:mathematics | source · DataCite | connector:datacite@1.0.0 | |
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