Omics · study · 2026
Comparative RNA-seq analysis of PM2.5-induced transcriptional responses in wildtype mouse mammary epithelial cells
Listed in NCBI GEO
Fine particulate matter (PM2.5) is an environmental pollutant associated with adverse health effects, including increased cancer risk.
Description
To investigate early transcriptional responses to PM2.5 exposure in non-malignant epithelial cells, we performed bulk RNA sequencing of wildtype mouse mammary epithelial EpH4 cells cultured under two-dimensional (2D) conditions. Cells were either left untreated or exposed to PM2.5.
This dataset captures genome-wide gene expression changes induced by PM2.5 in wildtype epithelial cells and provides insight into stress response and pathophysiological pathways activated upon particulate matter exposure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336715 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336715 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1482450 ncbi.nlm.nih.gov/bioproject/PRJNA1482450 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE336715 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |