Table · study · 2026
CRISPR interference screens in ALK+ anaplastic large cell lymphoma cell culture (SU-DHL-1) under treatment with therapies used in peripheral T-cell lymphoma treatment
Listed in NCBI GEO
The following are raw Illumina sequencing files for 14-day genome-wide CRISPR interference screens conducted in a T-cell lymphoma cell culture.
Description
This submission contains the results of two sets of genome-wide screens conducted at the University of North Carolina at Chapel Hill School of Medicine, in the lab of Adam Palmer. SU-DHL-1 cells stably expressing dCas9-KRAB (Addgene # 110820) were transduced with pCRISPRi-v2 genome-wide library (Addgene #84832) and treated for 14-days with either pralatrexate, romidepsin, oxaliplatin, gemcitabine, or bortezomib.
Deposited here are the raw high-throughput sequencing files, and the processed gene tables with phenotype scores, generated using the CRISPR interference screen data analysis pipeline originally published by Max Horlbeck from the lab of Jonathan Weissman.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330619 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330619 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1464694 ncbi.nlm.nih.gov/bioproject/PRJNA1464694 ↗
project · from NCBI GEO
- PubMed 42295240 pubmed.ncbi.nlm.nih.gov/42295240 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330619 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |