Omics · study · 2026
Genomic and Single Cell Investigation of MRD Modeling in Genetically Engineered Mouse Models of Multiple Myeloma
Listed in NCBI GEO
To study MRD and resistance to standard of care Revlimid, Velcade and dexamethasone (RVd) in MM, we utilized genetically engineered mouse models (GEMM) of human-like MM which carry cMYC, and IKK2 overexpression from germinal-center B cells.
Description
Upon development of the disease as determined by bone marrow (BM) aspirates and peripheral gamma protein fraction, mice were treated with RVd therapy for 20 weeks. BM specimens were collected at baseline, 8 weeks (when maximal response was observed, defined as MRD) and >20 weeks (refractory/resistance, RR) and profiled using whole-genome sequencing (WGS), bulk RNAseq (plasma cells alone and all remaining cells separately) and single cell RNAseq (scRNAseq) of non-sorted BM aspirates.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311701 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311701 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1370256 ncbi.nlm.nih.gov/bioproject/PRJNA1370256 ↗
project · from NCBI GEO
- PubMed 42498680 pubmed.ncbi.nlm.nih.gov/42498680 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Genome sequencing 65% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311701 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:genome-sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |