Omics · study · 2026
Deciphering the single-cell atlas of fetal donkey (Equus asinus) gonad development in early pregnancy
Listed in NCBI GEO
(1) Introduction: The ovaries are the reproductive organs of female animals and play a key role in fertility and maintaining endocrine balance.
Description
Gonadal development is a complex process that involves sex determination and subsequent maturation into the ovaries or testes. At present, the understanding of the mechanisms of donkey gonad development is still limited.
(2) Objectives: This study explores the comprehensive single-cell transcriptomics of donkey gonads, providing insights into the cellular and molecular events behind sex norms and gonad differentiation. (3)
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Methods
We used single-cell sequencing technology to construct a high-resolution map of fetal donkey gonad development, analyze the diversity and complexity of the cell composition of donkey gonads at different developmental stages, and reveal the characteristics of key cell types and gene expression patterns. (4) Results: The different cell states and active molecular pathways during the development of donkey gonadal tissue were revealed, and the gonadal ridge developed into ovary at 4-8 weeks.
(5) Conclusions: This study provides a foundational resource for understanding the complex biology of donkey gonadal development and may have implications for donkey reproductive health and fertility.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290288 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290288 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1227140 ncbi.nlm.nih.gov/bioproject/PRJNA1227140 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Animal developmental and reproductive biology 78% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE290288 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:field:310903 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (78%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |