Excel · study · 2026
Yiqi Huoxue Yangyin Decoction alleviates diabetic nephropathy by attenuating podocyte injury via the METTL3-m6A-mTOR pathway to activate autophagy
Listed in NCBI GEO
This study employed RNA-seq to profile the transcriptomic changes in the renal cortex of diabetic nephropathy (DN) mouse models and to investigate the regulatory effects of the traditional Chinese medicine formula Yiqi Huoxue Yangyin Decoction (YHY).
Description
Kidney cortex tissues were collected from diabetic db/db mice and non-diabetic db/m control mice. Db/db mice were further divided into two groups: one treated with YHY and one vehicle-treated.
Each group contained biological replicates (n=4).* Total RNA was extracted, and paired-end sequencing was performed on the Illumina NovaSeq 6000 platform. Differential gene expression analysis was conducted to identify genes and pathways altered by diabetes and modulated by YHY treatmen
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315612 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315612 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1398323 ncbi.nlm.nih.gov/bioproject/PRJNA1398323 ↗
project · from NCBI GEO
- PubMed 42016924 pubmed.ncbi.nlm.nih.gov/42016924 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE315612 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |