Omics · study · 2026
Shentong zhuyu decoction treatments regulate expression of inflammatory gene by potentially targeting transcription factors in dorsal root ganglia of rats with neuropathic pain
Listed in NCBI GEO
Shentong Zhuyu Decoction (STZYD) is a prescription of traditional Chinese medicine, which is widely used in many painful diseases including neuropathic pain (NPP).
Description
However, the potential pharmacological mechanism of STZYD is still unclear. The model of spinal nerve ligation (SNL) in rats was applied in this study.
Then, RNA sequencing (RNA-seq) was used to screen differentially expressed genes (DEGs) between NPP model rats treated with STZYD and those without STZYD, and 301 DEGs and 14 transcription factors (TFs) were found. The differential expression of TFs is involved in the inflammatory reaction, apoptosis, nerve invasion and neurotoxicity of NPP. Then, the correlation between DEGs obtained in this project and these 14 TFs was analyzed.
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It was found that 14 TFs and 170 DEGs were co-expressed, with a total of 715 relationship pairs. Some DEGs are enriched into multiple inflammatory immune response biological processes. Therefore, we speculate that the differential expression of immune inflammation-related TFs may participate in the treatment of NPP by STZYD through transcriptional regulation of the differential expression of its target.
The findings of this study provide a reference for further exploring the therapeutic targets of NPP.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE236nnn/GSE236592 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE236592 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA991610 ncbi.nlm.nih.gov/bioproject/PRJNA991610 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE236592 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |