Data · dataset · 2026
Developing lipid nanocapsules therapeutics for skin cancer
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32826017.v1
Skin cancer remains a significant global health burden, necessitating innovative approaches to improve treatment efficacy and patient outcomes.
Description
This thesis explores lipid nanocapsules (LNCs) as advanced drug delivery systems to address challenges associated with conventional therapies, such as poor drug solubility, limited cellular uptake, and suboptimal pharmacokinetics. A comprehensive study was conducted to develop, optimise, and evaluate LNC formulations for photothermal therapy (PTT) using indocyanine green (ICG) and for delivering poorly soluble drugs, including imiquimod (IMD).The research systematically investigates and evaluates the behaviour of LNCs across various drug delivery and therapeutic scenarios.
The research first focuses on optimising IMD-loaded LNCs by exploring modifications in the core and shell composition to improve encapsulation efficiency and biocompatibility. The findings demonstrated that oleic acid-enriched LNCs significantly enhanced drug loading capacity, while alternative surfactants minimised cytotoxicity. Then we investigated the cellular uptake and intracellular trafficking of LNCs, revealing that macropinocytosis is the principal endocytic pathway in melanoma cells.
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Our optimised Span80-containing LNCs (LNC100-S8) maintain lower cytotoxicity while achieving increased cellular uptake. These insights inform the design of more precise and effective nanocarrier systems. Finally, we evaluated the photothermal performance of indocyanine green (ICG)-loaded LNCs (ICG-LNC100-S8), revealing superior photothermal conversion efficiency and effective tumour ablation in 3D melanoma spheroid models.
The integration of nanotechnology and photothermal therapy showcases the synergistic potential of LNC-based platforms in treating skin cancer.The findings underscore the transformative potential of LNCs in improving therapeutic delivery, particularly for skin cancer. This work contributes to the field of nanomedicine by advancing our understanding of LNC properties and their application in cancer therapy.<br><br><i>Thesis is embargoed until 31 July 2027.</i>
Links
Where it is published
- DOI doi.org/10.17034/32826017.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Humanities · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75% · Pharmacology and pharmaceutical sciences 70%
Provenance · 3 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32826017 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32826017 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32826017 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3214 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:humanities | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |