Mov10 directly targets Camp to promote its protein synthesis

To validate the above hypothesis, we isolated Lin−c-Kit+ cell from Mov10fl/fl and Mov10-CKO mice after 12 days 4.5 Gy IR for translation sequencing (Ribo-seq) to analyze the effect of Mov10 on the translation efficiency of differentially expressed proteins and the abundance of ribosome-protected fragments (RPFs), funding protein translation efficiency of Camp is significantly downregulated after 12 days 4.5 Gy IR .

Ribo-seq genome browser views re-vealed strong ribosome stalling both at the Camp’s TISs and during the protein translation pro-cess of Camp after 12 days 4.5 Gy IR