Omics · study · 2026
miR-4711-5p suppresses the cancer stemness, proliferation and invasion activity in pancreatic cancer
Listed in NCBI GEO
Background/Aim: Pancreatic cancer is a highly malignant neoplasm and current treatment options have only shown minimal efficacy.
Description
Therefore, pancreatic cancer continues to have a poor prognosis, with the lowest 5-year survival rate and the development of efficient cancer therapeutics is desired. MiRNAs are involved in post-transcriptional regulation of gene expression and expected as a next generation cancer therapy.
Here, we investigated the anti-tumor effects of miR-4711-5p in pancreatic cancer cells. Materials and
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Methods
We investigated the effects of miR-4711-5p treatment on cell proliferation, cell cycle, apoptosis, cancer stemness, and invasion in pancreatic cancer cell lines. We also explored the novel target genes of miR-4711-5p in RNA sequencing and in silico analysis. Results: We showed that miR-4711-5p suppressed cancer stemness, cell proliferation, and invasion and induced cell cycle delay and apoptosis in pancreatic cancer cells.
MET, CASTA, and ANO1 were identified as potential target genes of miR-4711-5p. Conclusion: miR-4711-5p are potential therapeutic miRNAs in pancreatic cancer cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305461 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305461 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1306017 ncbi.nlm.nih.gov/bioproject/PRJNA1306017 ↗
project · from NCBI GEO
- PubMed 41976327 pubmed.ncbi.nlm.nih.gov/41976327 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305461 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |