Omics · study · 2026
Comprehensive Cytogenetic and Genomic Profiling of the Murine AML12 (Alpha Mouse Liver 12) Hepatocyte Cell Line
Listed in NCBI GEO
In our study, we aimed to provide a comprehensive cytogenetic and genomic profiling of the murine AML12 hepatocyte cell line.
Description
We established an integrated reference map that combines cytogenetics, short tandem repeat (STR) profiling, and transcriptomic analysis through RNA sequencing. Our findings reveal that AML12 maintains hepatocyte lineage identity while exhibiting partial de-differentiation and a complex karyotypic landscape characterized by a near-tetraploid chromosome set with recurrent structural rearrangements.
This study serves as a valuable resource for the scientific community, enhancing the understanding of AML12's genetic characteristics and its implications for future research in liver biology and related fields.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319199 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319199 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1422614 ncbi.nlm.nih.gov/bioproject/PRJNA1422614 ↗
project · from NCBI GEO
- PubMed 41827824 pubmed.ncbi.nlm.nih.gov/41827824 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 72% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319199 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |