Omics · study · 2026
Single-cell transcriptomic analysis of B-cell-dependent gastric cellular responses during chronic Helicobacter felis infection
Listed in NCBI GEO
Chronic Helicobacter infection induces gastric inflammation and metaplastic changes through interactions among epithelial, stromal, and immune-cell populations.
Description
This study used single-cell RNA sequencing to determine how B-cell deficiency alters the gastric cellular microenvironment during chronic Helicobacter felis infection. Total gastric cell suspensions were prepared from lesser-curvature tissue containing the fundus and corpus of uninfected wild-type, H. felis-infected wild-type, and H. felis-infected JH-deficient mice.
The dataset contains epithelial, stromal, and immune-cell populations and enables analysis of genotype- and infection-dependent differences in cellular composition, transcriptional programs, and intercellular communication.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346333 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346333 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1524989 ncbi.nlm.nih.gov/bioproject/PRJNA1524989 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346333 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |