Table · study · 2026
Spatial transcriptomic profiling of vascular compartments of chronic antibody-mediated rejection in kidney allografts identified compartment-specific signatures: a pilot study
Listed in NCBI GEO
Chronic antibody-mediated rejection (CAMR) is a leading cause of late kidney allograft loss, and its vascular compartments are the principal site of injury.
Description
To resolve compartment-specific transcriptomic programs, we applied GeoMx Digital Spatial Profiling with the Human NGS Whole Transcriptome Atlas (18,677 targets) to formalin-fixed paraffin-embedded kidney allograft biopsies. Forty-eight regions of interest (ROIs) were profiled across three vascular compartments (glomerulus, peritubular capillary, and vessel) in patients with CAMR or no evidence of rejection (NER), stratified by donor-specific antibody (DSA) status, together with normal (non-transplant) kidney as a control.
As a pilot study with one patient per group, this dataset is intended to be descriptive and hypothesis-generating rather than definitive.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342778 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342778 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1508883 ncbi.nlm.nih.gov/bioproject/PRJNA1508883 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 69% · Sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342778 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |