Data · dataset · 2026
Prenatal origins of pathology in a Classic Galactosemia zebrafish model
Listed in IISH Dataverse
Despite early dietary galactose restriction, most patients with Classic Galactosemia (CG) develop long-term complications affecting the brain and ovaries.
Description
Prenatal contributions to disease pathology have been proposed. We investigated the developmental trajectory of CG-associated transcriptional signatures in our galt knockout (KO) zebrafish model.
RNA sequencing was performed on galt KO and wild-type embryos, larvae and juvenile zebrafish. Differentially expressed genes were analyzed using KEGG and GO enrichment, and metabolic pathway changes were assessed with MetaPhOR.
Links
Where it is published
- Dataverse dataset page dataverse.nl/dataset.xhtml?persistentId=doi%3A10.34894%2FXNVSGK ↗
landing page · from datasets iisg amsterdam
- DOI doi.org/10.34894/xnvsgk ↗
DOI / persistent id · from datasets iisg amsterdam
Catalogue records · 1
- Dataverse API dataverse.nl/api/datasets/:persistentId/?persistentId=doi%3A10.34894%2FXNVS… ↗
metadata API · from datasets iisg amsterdam
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Danio rerio · Life Sciences · Medicine & Health
- Inferred from text
- Disease 75% · Nutrition and dietetics 69% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| IISH Dataverse | doi:10.34894/XNVSGK | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:disease | enrichment · datasets iisg amsterdam | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3210 | enrichment · datasets iisg amsterdam | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[modality].local:modality:rna-seq | enrichment · datasets iisg amsterdam | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · datasets iisg amsterdam | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:7955 | mapping · datasets iisg amsterdam | vocabulary-mapper@1.0.0 | keywords['Zebrafish'] |
| created_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| description | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /description |
| publication_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| title | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /name |
| updated_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| version_label | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 |