Data · study · 2026
Expression data of hippocampal neural stem cells from rat
Listed in NCBI GEO
Neural stem cells (NSCs) are essential for brain development and adult hippocampal neurogenesis, yet early-life environmental stress may induce persistent dysfunction through epigenetic mechanisms.
Description
In this study, we investigated the long-term effects of maternal high-fructose corn syrup (HFCS) intake on NSCs using a rat DOHaD model. Maternal HFCS exposure induced persistent impairments in NSC proliferation and differentiation, accompanied by hippocampus-dependent cognitive dysfunction in offspring.
Mechanistically, transient downregulation of Dnmt3a in fetal NSCs was associated with sustained repression of Spp1, encoding intracellular osteopontin (iOPN), a regulator of NSC function. We performed Affymetrix Clariom S microarray analyses of hippocampal NSCs isolated from offspring of control and maternal HFCS-fed rats and identified transcriptomic alterations associated with maternal HFCS exposure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE332nnn/GSE332845 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332845 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1469163 ncbi.nlm.nih.gov/bioproject/PRJNA1469163 ↗
project · from NCBI GEO
- PubMed 42392085 pubmed.ncbi.nlm.nih.gov/42392085 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 69%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE332845 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |