Omics · study · 2026
Transcriptional identity of murine healthy spleenic, tumor-bearing splenic and tumoral Treg cells.
Listed in NCBI GEO
CRC-organoids were implanted in the liver of Foxp3eGFP mice to investigate the phenotypic differences of TI-Treg cells in vivo dependent on location.
Description
After tumor development, T cells from distinct metastatic sites were isolated and analyzed. RNA sequencing of Treg cells from the spleen, "primary" liver tumors, and metastases revealed that TI-Treg cells expressed core genes previously associated with CRC-related Treg cells, with subtle location-specific variations.
Gene Ontology analysis highlighted enriched immune response regulation pathways in primary liver TI-Treg cells compared to healthy splenic Treg cells. High expression of genes upregulated in liver TI-Treg cells was associated with poor CRC prognosis. Splenic Treg cells from tumor-bearing mice also displayed distinct transcriptional profiles from their healthy counterparts.
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These findings highlight that TI-Treg cells have transcriptional profiles linked to poor CRC prognosis, with subtle location-specific variations.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275756 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275756 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1152914 ncbi.nlm.nih.gov/bioproject/PRJNA1152914 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE275756 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |