Data · dataset · 2025
Single-cell transcriptomic dissection of two waves of endothelial-hematopoietic transition in murine yolk sac
Listed in ScienceDB
The yolk sac drives vertebrate embryonic hematopoiesis through primitive hematopoiesis and endothelial-to-hematopoietic transition (EHT) waves, yet dynamic cellular and molecular changes during EHT of yolk sac require elucidation.
Description
By integrating single-cell transcriptomic data from mouse embryos (E6.75-E11.0), we built a comprehensive atlas of early endothelial and hematopoietic development in yolk sac. Focusing on the yolk sac (E7.5-E9.5), we established a refined atlas capturing key cell populations of EHT in yolk sac.The repository contents:[‘merged_data.rds’] contains the Seurat Object v4 of single-cell RNA sequencing data related to Figure 1B.
It includes integrated data from early whole embryo and yolk sac sampling sites. The meta.data of scRNA-seq object contains the properties of each observed cell are defined as follows: data_source: origin of raw data. location: Sampling site of mouse embryo. method: sequencing technology used for the raw data. stage: mouse embryonic developmental stages. Cluster: defines major cell types of each cell. [‘merged_yolksac.rds’] contains a Seurat Object (v4) of single-cell RNA sequencing data.
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This corresponds to the data presented in Figure 4A, and includes integrated data from yolk sac endothelial and hematopoietic cells. The meta.data of scRNA-seq object contains the properties of each observed cell are defined as follows: source: origin of raw data. location: Sampling site of mouse embryo. stage: mouse embryonic developmental stages. method: sequencing technology used for the raw data.batch: batch effect from different sequencing approaches and data. celltype_new: defines major cell types of each cell.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.28974 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75% · Zoology 70%
Provenance · 1 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.28974 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:3109 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (70%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |