Text · study · 2026
Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL6/J mice
Listed in NCBI GEO
Olfactory dysfunction (loss of the ability to detect odors) is a prevalent symptom and an early marker of age-related neurodegenerative diseases in humans, including Alzheimer’s Disease and Parkinson’s Disease.
Description
However, as olfactory dysfunction also is a common symptom of normal aging, it is important to identify associated behavioral and mechanistic changes that underlie olfactory dysfunction in nonpathological aging.
In the present study, we systematically investigated age-related behavioral changes in four specific domains of olfaction and the molecular basis in C57BL6/J mice. Our results show that selective loss of odor discrimination is the earliest smelling behavioral change with aging, followed by a decline in odor sensitivity and identification. Compared to behavioral changes related with memory and motor functions, smelling loss is among one of the earliest biomarkers of aging.
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During aging, metabolites related with of oxidative stress, osmolytes and infection become dysregulated in the olfactory bulb, and G protein coupled receptor related signaling was significantly down regulated in olfactory bulb of aged mice. Poly ADP-ribosylation levels and protein expressions of DNA damage markers and inflammation increased significantly in the olfactory bulb of older mice in which a lower NAD+ level was also detected.
Supplementation of NAD+ through NR in water improved longevity and partially enhanced olfaction in aged mice.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE204nnn/GSE204966 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE204966 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA842778 ncbi.nlm.nih.gov/bioproject/PRJNA842778 ↗
project · from NCBI GEO
- PubMed 36846960 pubmed.ncbi.nlm.nih.gov/36846960 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE204966 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |