Data · dataset · 2026
Development of biomaterial-based 3D printed drug-eluting scaffolds for bone cancer applications
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32826068.v1
Bone cancer remains a predominant site of metastatic progression and poses substantial therapeutic challenges, highlighting the need for customised drug delivery systems (DDSs), such as implantable devices, to address the limitations of conventional therapies and improve clinical outcomes.
Description
This study investigates the design and development of novel and multifunctional 3D printed scaffolds aimed at simultaneous pain management, segmental bone defect repair, and adjuvant treatment for bone metastases.
Initially, procaine (PRC) loaded biopolymeric scaffolds composed of poly(caprolactone) (PCL) and chitosan (CS) were developed for localised post-operative multimodal analgesia, achieving a sustained release. Subsequently, composite scaffolds consisted of PCL and the bioceramics hydroxyapatite (HA) or b-tricalcium phosphate (TCP) were engineered to systematically assess their physicochemical, mechanical characteristics and cytocompatibility, with the overarching objective of advancing bone-mimetic implant design.
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In the next step HA microparticles were functionalised with zoledronic acid (ZLD) and incorporated into PCL 3D printed scaffolds, establishing a localised, sustained release platform as potential adjuvant treatment for cytotoxic agents and osteoclast resorption inhibition. Finally, multi-material 3DP was employed for the fabrication of PCL-based multi-layer scaffolds, as multifunctional drug-loaded platforms, with adjusted geometrical features aiming to enhance vascularisation and tissue regeneration.
Overall, this thesis demonstrated that comprehensive optimisation of biomaterial formulations and processing parameters enabled the fabrication of reproducible, mechanically robust scaffolds with sustained drug release, advancing customised biomaterial-based DDSs as promising strategies for customised and multimodal bone cancer treatment.<br><br><i>Thesis is embargoed until 31 December 2030.</i>
Links
Where it is published
- DOI doi.org/10.17034/32826068.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75% · Pharmacology and pharmaceutical sciences 71%
Provenance · 3 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32826068 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32826068 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32826068 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3214 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |