Data · collection · 2015
Effects of adiponectin polymorphisms on the risk of advanced age-related macular degeneration
Listed in DataCite
Objective : To determine the relationships between variants in adiponectin gene ( ADIPOQ ) with advanced forms of age-related macular degeneration (AMD) susceptibility.
Description
Methods
A total of 189 advanced AMD patients and 168 controls were recruited. Seven tagging single-nucleotide polymorphisms in ADIPOQ were genotyped by the SNaPshot method. Results : Alleles or genotypes of rs822396 distributed significantly differently in advanced AMD patients and controls.
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The minor allele G at rs822396 was associated with an increased risk of advanced AMD in a dominant model. Furthermore, haplotype analysis revealed that haplotypes AGGACCT and TGACCCC were significantly increased the advanced AMD susceptibility, whereas haplotypes AGAACGC, TGAACGT and TGACAGC had protective effects. Conclusion : ADIPOQ genetic variant rs822396 might affect an individual’s susceptibility to AMD, making it efficient genetic biomarkers for early detection of AMD.
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Where it is published
- Repository landing page tandf.figshare.com/collections/Effects_of_adiponectin_polymorphisms_on_the_risk_o… ↗
landing page · from DataCite
- Repository landing page tandf.figshare.com/collections/Effects_of_adiponectin_polymorphisms_on_the_risk_o… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2114960 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2114960.v1 ↗
DOI / persistent id · from DataCite
Documentation and papers
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2114960.v1 ↗
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- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2114960 ↗
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- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2114960.v1 ↗
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Topics
- Stated by source
- Biological sciences · Biological sciences · Mathematics · Mathematics
- From keywords
- Ecology · Genetics · Life Sciences · Life Sciences · Mathematics & Statistics · Mathematics & Statistics · Medicine & Health · Medicine & Health
Provenance · 2 source records, 17 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.2114960 | 14 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.c.2114960.v1 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:mathematics | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:mathematics | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Biological Sciences'] |
| concepts[field].local:field:life-sciences | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Biological Sciences'] |
| concepts[field].local:field:mathematics-statistics | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Mathematics'] |
| concepts[field].local:field:mathematics-statistics | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Mathematics'] |
| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |