Excel · study · 2026
Transcriptomic sequencing reveals gene expression profiles underlying photobiomodulation-mediated amelioration of hypobaric hypoxia-induced synaptic plasticity deficits in mice
Listed in NCBI GEO
Photobiomodulation is a neuromodulation technique that employs lasers and light-emitting diodes to stimulate neural activity and improve brain function, demonstrating favorable clinical outcomes in the treatment of various neurological and neuropsychiatric disorders.
Description
In this study, we applied 1064 nm laser-based photobiomodulation to address brain dysfunction induced by hypobaric hypoxia exposure. Hypobaric hypoxia impairs synaptic plasticity, leading to cognitive deficits in mice.
Our findings suggest that photobiomodulation preserves synaptic plasticity homeostasis through the PI3K-Akt, cAMP-PKA, and calcium signaling pathways, with Adora2a identified as a potential key driver molecule and therapeutic target underlying the beneficial effects of photobiomodulation on hypobaric hypoxia-induced cognitive dysfunction.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325653 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325653 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1441425 ncbi.nlm.nih.gov/bioproject/PRJNA1441425 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 70% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE325653 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |