Data · dataset · 2026
QUB-1453: A Bioactive Peptide from the Defensive Skin Secretion of Rana amurensis
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32862566.v1
Amphibian skin secretion is one of the richest sources for antimicrobial peptides (AMPs) which have potent bioactivity and pharmaceutical value for new drug development.
Description
In this thesis, QUB-1452, an AMP, was isolated and characterised from the skin secretion of Rana amurensis. The peptide is composed of 13 amino acid residues, FLPVLISLIGRLL, and is C-terminally amidated.
The structure and functions of QUB-1452 were identified via nucleotide/amino acid sequencing and bioactivity analyses. The results showed that QUB-1452 had relatively strong antimicrobial activity against S. aureus (Staphylococcus aureus) and C. albicans (Candida albicans) with minimal inhibitory concentrations of 8 µmol/L and 16 µmol/L respectively, while it had little effect on the growth of E. coli (Escherichia coli).
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In addition, QUB-1452 had high haemolytic activity at high concentrations, whereas the haemolytic activity was relatively low at the minimal inhibitory concentrations against S. aureus and C. albicans at 3.3% and 6.6%, respectively. Moreover, the peptide had no effect on cancer cells. These data demonstrate the potential of amphibian skin secretions to provide novel natural peptide templates for biological evaluation.
Links
Where it is published
- DOI doi.org/10.17034/32862566.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Cancer 75% · Sequencing 75%
Provenance · 3 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32862566 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32862566 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32862566 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[modality].local:modality:sequencing | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |