Data · dataset · 2025
Characterization of the Intrahepatic Microbiome in Patients with HBV-Related End-Stage Liver Disease
Listed in ScienceDB
This study investigates the intrahepatic microbiome in hepatitis B virus (HBV) related end stage liver disease (ESLD).
Description
Liver tissue samples from 20 patients with decompensated cirrhosis (DC), 24 with acute on chronic liver failure (ACLF), and 18 healthy donors (total n=62) were analyzed by metatranscriptomic sequencing (~200M reads per sample) to profile microbial and host transcriptomes. A total of 2208 bacterial species across 13 phyla and 165 genera were identified, with Proteobacteria and Actinobacteria dominating.
Patients with DC and ACLF showed distinct microbial community structures compared with donors, with enrichment of specific gut, oral and respiratory derived taxa. Functional analysis indicated activation of Escherichia coli in ESLD, highlighting intrahepatic microbiome reprogramming and potential diagnostic and therapeutic value.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.29617 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Disease 75% · Sequencing 75%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.29617 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |