Data · dataset · 2016
Identification of processing elements and interactors implicate SMN, coilin and the pseudogene-encoded coilp1 in telomerase and box C/D scaRNP biogenesis
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Many cellular functions, such as translation, require ribonucleoproteins (RNPs).
Description
The biogenesis of RNPs is a multi-step process that, depending on the RNP, can take place in many cellular compartments. Here we examine 2 different RNPs: telomerase and small Cajal body-specific RNPs (scaRNPs).
Both of these RNPs are enriched in the Cajal body (CB), which is a subnuclear domain that also has high concentrations of another RNP, small nuclear RNPs (snRNPs). SnRNPs are essential components of the spliceosome, and scaRNPs modify the snRNA component of the snRNP. The CB contains many proteins, including WRAP53, SMN and coilin, the CB marker protein.
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We show here that coilin, SMN and coilp1, a newly identified protein encoded by a pseudogene in human, associate with telomerase RNA and a subset of scaRNAs. We also have identified a processing element within box C/D scaRNA. Our findings thus further strengthen the connection between the CB proteins coilin and SMN in the biogenesis of telomeras e and box C/D scaRNPs, and reveal a new player, coilp1, that likely participates in this process.
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Where it is published
- Repository landing page tandf.figshare.com/articles/dataset/Identification_of_processing_elements_and_int… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.3487649 ↗
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Documentation and papers
- Creative Commons Attribution 4.0 International creativecommons.org/licenses/by/4.0/legalcode ↗
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- IsSupplementTo 10.1080/15476286.2016.1211224 doi.org/10.1080/15476286.2016.1211224 ↗
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Topics
- Stated by source
- Biological sciences · Health sciences · Physical sciences
- From keywords
- Cancer
Related
Provenance · 1 source records, 12 field assertions
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|---|---|---|---|
| DataCite | 10.6084/m9.figshare.3487649 | 14 d ago | JSON v1 |
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