Omics · study · 2026
Transcriptomic profiling of blood neutrophils from preterm infants with bronchopulmonary dysplasia
Listed in NCBI GEO
Bronchopulmonary dysplasia (BPD) is a major complication of preterm birth, yet its immune mechanisms remains poorly understood.
Description
To explore the role of neutrophils in the pathogenesis of BPD, a prospective study was conducted in the Neonatal Intensive Care Unit of Guangzhou Women and Children’s Medical Center from June to September 2024. Inclusion criteria were: (1) preterm birth at <32 weeks of gestational age, and (2) admission within 6 hours after birth.
Peripheral blood samples were collected on day 14 after birth. Infants with major congenital anomalies or acute infections were excluded. A total of 22 preterm infants were enrolled, of whom 12 developed BPD.
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Neutrophils were isolated from peripheral blood, and bulk RNA sequencing was performed.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305315 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305315 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1305285 ncbi.nlm.nih.gov/bioproject/PRJNA1305285 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305315 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |