Omics · study · 2026
IL-17 signaling pathway and NMDAR1 antibodies shape NMDAR encephalitis
Listed in NCBI GEO
Human forebrain organoids (hFOs, day 110) derived from U2F iPS cell line were exposed with or without 10 μg/mL anti-NMDAR1 antibody for 24 hours.
Description
Organoids were then randomly selected for RNA sequencing (RNA-seq). By performing RNA-seq analysis, we showed that anti-NMDAR1 antibody exposure in hFOs downregulated expression of genes enriched with multiple neuronal functions including the glutamatergic synapse.These downregulated genes were also enriched with neuropsychiatric disorder-related genes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE256nnn/GSE256148 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE256148 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1078331 ncbi.nlm.nih.gov/bioproject/PRJNA1078331 ↗
project · from NCBI GEO
- PubMed 41436585 pubmed.ncbi.nlm.nih.gov/41436585 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE256148 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |