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Omics · study · 2026

Single-cell whole-genome DNA methylation profiling of whole blood from PASC patients and healthy controls

Listed in NCBI GEO

We performed single-cell whole-genome bisulfite sequencing (scWGBS) on whole blood samples from three individuals with Post-Acute Sequelae of SARS-CoV-2 (PASC/Long COVID) and three healthy control individuals to characterize cell-type-specific DNA methylation alterations associated with PASC.

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Libraries were prepared using the ScaleMethyl combinatorial indexing platform (Scale Biosciences). Six samples were multiplexed using unique barcode combinations and sequenced together.

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Homo sapiens · Methylation profiling by high throughput sequencing
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Life Sciences
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DNA methylation profiling 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE34109415 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:methylation-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[method].local:method:dna-methylation-profilingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title