Hepatocyte-derived sIL1RAP restrains chronic inflammation under dietary

In this study, bulk RNA sequencing was performed on liver tissues from control mice fed a chow diet, GAN diet-induced MASH mice treated with a control AAV vector, and GAN diet-induced MASH mice treated with hepatocyte-targeted AAV-sIL1RAP.

This dataset was designed to characterize GAN diet-induced hepatic transcriptional alterations and to assess whether restoration of hepatocyte-derived soluble interleukin-1 receptor accessory protein (sIL1RAP) attenuates inflammation-associated transcriptional responses. Comparative transcriptomic analysis showed that the GAN diet enhanced inflammatory transcriptional programs, including NF-κB-related signaling, whereas hepatocyte-specific restoration of sIL1RAP mitigated these changes.