Omics · study · 2026
Transcriptome analysis of LepR knockout golden hamsters
Listed in NCBI GEO
To investigate the functional role of LepR in golden hamsters, we performed RNA sequencing on LepR-knockout golden hamsters and their control group (wild-type golden hamsters).
Description
Further analysis revealed that LepR knockout led to the development of diabetic phenotypes in golden hamsters, with changes primarily driven by activation of inflammatory pathways, as well as dysregulation of lipid metabolism and the extracellular matrix.
Thus, our study provides a novel animal model for the development of diabetes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327492 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327492 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1451078 ncbi.nlm.nih.gov/bioproject/PRJNA1451078 ↗
project · from NCBI GEO
- PubMed 42666243 pubmed.ncbi.nlm.nih.gov/42666243 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327492 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |