Omics · study · 2026
KRAS-G12C inhibition induces enrichment of immune-active malignant cells to augment immune-effector TME development
Listed in NCBI GEO
KRASG12C inhibitors have demonstrated promising clinical activity in KRASG12C-mutant cancers; however, therapeutic resistance commonly emerges.
Description
To investigate the impact of KRASG12 inhibition on the tumor microenvironment and its potential role in resistance, we performed single-cell RNA sequencing (scRNA-seq) on murine lung and colon carcinoma models harboring KRASG12mutations following treatment with the KRASG12 inhibitor sotorasib.
Transcriptomic profiling revealed a marked reduction in proliferative tumor cell populations and an enrichment of immune-active tumor cells characterized by elevated NF-κB and interferon signaling. These data provide a high-resolution view of tumor and immune cell state changes induced by KRASG12 inhibition and offer insights into mechanisms of therapeutic response and resistance.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335907 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335907 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1479804 ncbi.nlm.nih.gov/bioproject/PRJNA1479804 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335907 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |