Omics · study · 2026
Transcriptomic profiling of upper incisor tissues from neural crest-specific Alx1 conditional knockout mice at embryonic day 13.5
Listed in NCBI GEO
Tooth morphogenesis depends on reciprocal interactions between the dental epithelium and neural crest-derived mesenchyme.
Description
ALX1 is a paired-like homeodomain transcription factor implicated in craniofacial development, yet its molecular function during tooth development remains poorly understood. To investigate the transcriptional changes associated with loss of Alx1 during early odontogenesis, we performed bulk RNA sequencing of upper incisor tissues isolated from embryonic day 13.5 (E13.5) neural crest-specific Alx1 conditional knockout mice (Wnt1-Cre;Alx1 flox/flox) and littermate wild-type controls.
This dataset provides a comprehensive transcriptomic resource for identifying genes and signaling pathways regulated by Alx1 during early upper incisor development.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336212 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336212 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1481076 ncbi.nlm.nih.gov/bioproject/PRJNA1481076 ↗
project · from NCBI GEO
- PubMed 42755507 pubmed.ncbi.nlm.nih.gov/42755507 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE336212 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |