Data · study · 2026
MUC21 is downregulated in oral squamous cell carcinoma and associated with poor prognosis
Listed in NCBI GEO
The role of MUC21 in oral squamous cell carcinoma (OSCC) remains unexplored.
Description
Microarray data of 10 paired OSCC and adjacent normal oral mucosae (para-OSCC) from this study and datasets from GEO and TCGA RNA-seq were analyzed to screen out differentially expressed genes including MUC21 which was further validated by qRT-PCR. the impact of expression changes of MUC21 on OSCC was retrospectively studied by clinical data, MUC21 immunohistochemistry data from a cohort of patients.
In vitro OSCC cell lines experiments were also conducted to further verify the results.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325374 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325374 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1439813 ncbi.nlm.nih.gov/bioproject/PRJNA1439813 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE325374 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |