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Omics · study · 2026

Bulk RNA sequencing of optic nerves from wild-type and oligodendrocyte HRasG12V mutant mice

Listed in NCBI GEO

Learning issues in the complex wheel test were observed two weeks after inducing the Costello syndrome-causing mutation HRasG12V in adult mouse oligodencrocytes.

Description

Bulk RNA sequencing of optic nerves (rich in oligodendrocytes) was performed to identify transcriptional changes after induction of HRasG12V expression. Optic nerves were collected from wild-type and pHRasG/+ male mice two weeks after tamoxifen-induced recombination.

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Expression profiling by high throughput sequencing · Mus musculus
From keywords
Life Sciences
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RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE34626815 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title