Antidepressant Mechanism of Acorus tatarinowii Volatile Oil via Inhibition of Microglial Polarization Through the TNF/NF-κB/NLRP3 Signaling Pathway

Visualization analysis is performed on a bioinformatics platform. In vitro and in vivo experiments were conducted using Western Blot to detect the expression levels of TNF/NF - κ B/NLRP3 pathway proteins (p-NF - κ Bp65/NF - κ Bp65, p-I κ B α/I κ B α, TNF - α, PTGS2, NLRP3, Caspase-1, IL-1 β) and microglial M1/M2 phenotype markers (CD16/32, CD206).

Data analysis and statistical graphs were performed using GraphPad Prism 9.