Data · dataset · 2013
Multiparametric comparative analysis of all pre- and postinfection related immune cell and clinical traits
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Multiparametric analysis of 233 MA/My x C57L intercross and backcross mice segregating MHC class I Dk.
Description
Before murine (M)CMV infection, all mice were weighed and bled. Blood leukocytes were stained with fluorochrome-conjugated mAbs for CD3, CD19, and NK receptors and then analyzed by flow cytometry.
NK cell subset light-scattering features, absolute number, frequency, and receptor display intensity were recorded as individual pre-infection traits. Afterward, the mice were infected with MCMV. Spleen and liver tissues were collected 3.5 d later for analysis of postinfection traits, including genomic genotypes and viral load.
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Spleen leukocytes from infected mice were analyzed as for pre-infection traits. The change in trait values were calculated from the pre- (blood) and post- (spleen) infection trait values. In total, 110 distinct traits were assessed.
Multiparametric Pearson correlations were performed in the R (versions 2.15.0 and 2.15.2) computing environment using an automated correlation analysis followed with a strict Bonferroni correction for multiple tests. P-values were corrected for multiple comparisons using both the Benjamini-Hochberg false discovery rate and the Bonferroni Correction.
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Where it is published
- Repository landing page figshare.com/articles/dataset/Multi_parametric_comparative_analysis_of_all_… ↗
landing page · from DataCite
- Repository landing page figshare.com/articles/dataset/Multi_parametric_comparative_analysis_of_all_… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.768435 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.768435.v4 ↗
DOI / persistent id · from DataCite
Documentation and papers
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.768435.v4 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.768435 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.768435.v4 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.768435 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Biological sciences · Biological sciences · Clinical medicine · Clinical medicine · Health sciences · Health sciences
Related
Provenance · 2 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.768435 | 15 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.768435.v4 | 15 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:health-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:health-sciences | source · DataCite | connector:datacite@1.0.0 | |
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| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
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| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
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