Excel · study · 2026
Transcriptome profiling of parental and lenvatinib-resistant TPC-1 thyroid cancer cells
Listed in NCBI GEO
To uncover transcriptional alterations associated with lenvatinib resistance in papillary thyroid carcinoma, we performed paired-end RNA-Seq (2 × 150 bp, NovaSeq 6000) on parental TPC-1 cells and an in-house generated lenvatinib-resistant sub-line (TPC-1-Len).
Description
Total RNA from three biological replicates per group was extracted with TRIzol, libraries were prepared with poly(A) selection, and sequencing was carried out at OE Biotech (Shanghai, China).
Differential gene expression was analysed using DESeq2 (Q < 0.05)
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300132 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300132 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1279090 ncbi.nlm.nih.gov/bioproject/PRJNA1279090 ↗
project · from NCBI GEO
- PubMed 41991644 pubmed.ncbi.nlm.nih.gov/41991644 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE300132 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |