Omics · study · 2026
Fetal erythropoiesis and hemoglobin regulation in the context of maternal obesity
Listed in NCBI GEO
We employed single-cell RNA sequencing (scRNA-seq) to investigate the impact of maternal obesity (MO) on embryonic erythropoiesis across multiple hematopoietic organs during mouse development.
Description
Tissues including E13.5 placenta, yolk sac, and liver, as well as E17.5 fetal liver, were collected from embryos of obese and control dams. Our analysis revealed dynamic changes in erythroid lineage composition, maturation states, and hemoglobin gene regulation under MO conditions.
This dataset provides a comprehensive single-cell transcriptional map of developing erythroid cells across distinct anatomical sites and developmental stages in response to maternal metabolic stress, offering insights into how maternal obesity disrupts embryonic hematopoiesis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303768 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303768 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1297647 ncbi.nlm.nih.gov/bioproject/PRJNA1297647 ↗
project · from NCBI GEO
- PubMed 42538850 pubmed.ncbi.nlm.nih.gov/42538850 ↗
publication · from NCBI GEO
- PubMed 42667065 pubmed.ncbi.nlm.nih.gov/42667065 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303768 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |