Data · dataset · 2025
RNA-seq Data of Short Chain Fatty Acids Exposed Human Kidney Proximal Tubule Cells
Listed in IISH Dataverse
This dataset contains RNA sequencing (RNA-seq) data from human conditionally immortalized proximal tubule epithelial cells (ciPTEC-OAT1) exposed to microbiota-derived short-chain fatty acids (SCFAs): acetate, propionate, and butyrate.
Description
Cells were treated individually or in combination with 1 mM of each SCFA for 24 hours under 2D culture conditions. The aim was to investigate the transcriptomic changes underlying SCFA-mediated modulation of renal secretory function, particularly the expression and activity of the organic anion transporter 1 (OAT1/SLC22A6).
The data were generated as part of a study exploring the epigenetic and signaling mechanisms (e.g., HDAC inhibition, cAMP and PI3K-Akt pathway activation) through which SCFAs influence kidney tubular transporter expression. The results support a role for SCFAs in enhancing renal excretory function, with potential implications for nutritional interventions in chronic kidney disease (CKD) management.
Links
Where it is published
- Dataverse dataset page dataverse.nl/dataset.xhtml?persistentId=doi%3A10.34894%2FPH09FP ↗
landing page · from datasets iisg amsterdam
- DOI doi.org/10.34894/ph09fp ↗
DOI / persistent id · from datasets iisg amsterdam
Catalogue records · 1
- Dataverse API dataverse.nl/api/datasets/:persistentId/?persistentId=doi%3A10.34894%2FPH09… ↗
metadata API · from datasets iisg amsterdam
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Medicine & Health
- Inferred from text
- Disease 75% · Medical biochemistry and metabolomics 69% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| IISH Dataverse | doi:10.34894/PH09FP | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:disease | enrichment · datasets iisg amsterdam | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3205 | enrichment · datasets iisg amsterdam | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[modality].local:modality:rna-seq | enrichment · datasets iisg amsterdam | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · datasets iisg amsterdam | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| description | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /description |
| publication_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| title | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /name |
| updated_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| version_label | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 |