Excel · study · 2026
CS2164 combined with radiation impaired tumor growth by interfering with DNA damage repair and modifying tumor environment
Listed in NCBI GEO
CS2164 is an oral anti-tumor inhibitor that targets angiogenesis-related kinases, mitosis-related kinases, and chronic inflammation-related kinases.
Description
However, the added clinical benefit of CS2164 combined with radiation remains unknown. The hepatocellular carcinoma and cervical cancer cell lines were selected to evaluate the anti-tumor effect of CS2164 combined with radiation using cell growth and colony formation assays.
Further, xenograft radiation models were constructed to evaluate in vivo effects. Finally, transcriptome sequencing and bioinformatics analysis were performed to elucidate the mechanisms. In this study, we found that CS2164 combined with radiation significantly decreased growth of tumors in vitro and in vivo.
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The γ-H2AX immunofluorescence staining results indicated that CS2164 enhanced radiation-induced DNA double strand breaks (DSBs) and suppressed the DNA damage repair process. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis screened out a series of pathways that related to cell death types and immune tolerances, in the CS2164 plus radiation group compared with the control group. Meanwhile, protein-protein interaction regulator network was used to determine the core regulatory molecules landscape, including DNA damage repair process, microtubule formation, calcium channels, etc.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312448 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312448 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1373332 ncbi.nlm.nih.gov/bioproject/PRJNA1373332 ↗
project · from NCBI GEO
- PubMed 41845287 pubmed.ncbi.nlm.nih.gov/41845287 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312448 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |