Omics · study · 2026
CD84 Determines Differential Fates of Pro-fibrotic Macrophages [RNA-seq]
Listed in NCBI GEO
To define the transcriptional effects of CD84 engagement, bone marrow-derived macrophages (BMDMs) from wild-type and Cd84-knockout mice were stimulated with mouse recombinant CD84 (rCD84) and analyzed by bulk RNA sequencing.
Description
CD84 engagement induced inflammatory, chemotactic, survival, and adhesion-related gene programs in wild-type macrophages, whereas these responses were markedly reduced by Cd84 deletion. Pathway analysis highlighted cytokine activity, inflammatory responses, leukocyte chemotaxis, focal adhesion, TNF signaling, and JAK/STAT signaling.
These findings establish CD84 as a key regulator of macrophage activation and pro-fibrotic transcriptional programming.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344928 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344928 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1517984 ncbi.nlm.nih.gov/bioproject/PRJNA1517984 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE344928 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |