Data · collection · 2016
Antiprotozoal activity of major constituents from the bioactive fraction of Verbesina encelioides
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The bioactive petroleum ether fraction of Verbesina encelioides , previously studied by the authors, was chosen for the isolation of antiprotozoal metabolites.
Description
Pseudotaraxasterol-3β-acetate ( 1 ), benzyl 2,6-dimethoxy benzoate ( 2 ), 16β-hydroxy-pseudotaraxasterol-3β-palmitate ( 3 ) and pseudotaraxasterol ( 4 ), in addition to β -sitosterol glucoside ( 5 ) and β -sitosterol galactoside ( 6) were isolated and identified based on one-dimensional and two-dimensional spectral analysis.
This is the first report describing (3) and (6) in genus Verbesina . The isolated compounds were tested in vitro against Plasmodium falciparum , Trypanosoma brucei , Trypanosoma cruzi and Leishmania infantum . Cytotoxicity was evaluated on MRC-5 cells.
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Compound 1 showed moderate to weak activity against L. infantum T. brucei and P. falciparum and was inactive against T. cruzi. Compound 3 showed moderate activity against L. infantum , compound 4 revealed weak activity against T. cruzi , while 5 and 6 were inactive against all tested protozoa. All compounds were non-cytotoxic.
The isolated constituents showed less antiprotozoal activity than the crude fraction.
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- Repository landing page figshare.com/collections/Antiprotozoal_activity_of_major_constituents_from_… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.3241405 ↗
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- CC-BY creativecommons.org/licenses/by/3.0/us ↗
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Catalogue records · 2
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.3241405 ↗
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Topics
- Stated by source
- Biological sciences · Chemical sciences · Earth and related environmental sciences · Physical sciences
- From keywords
- Medicine & Health
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.3241405 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:chemical-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:earth-and-related-environmental-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:physical-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |