Excel · study · 2026
Jejunal gene expression in surfactant protein D (Sftpd) knockout and wild-type mice after doxorubicin-induced intestinal toxicity
Listed in NCBI GEO
Surfactant protein D (SP-D, gene Sftpd) is an anti-inflammatory host defence collectin produced by epithelial cells on mucosal surfaces.
Description
We investigated whether SP-D attenuates chemotherapy-induced gastrointestinal toxicity and inflammation in mice. Sftpd-/- (KO) mice and Sftpd+/+ (WT) littermates received a single intraperitoneal injection of doxorubicin (20 mg/kg) or isotonic saline and were sacrificed on day 3 or day 7.
Genome-wide expression in the jejunum was profiled on the Affymetrix GeneChip Mouse Transcriptome Array 1.0.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335354 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335354 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1477982 ncbi.nlm.nih.gov/bioproject/PRJNA1477982 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335354 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |