Omics · study · 2026
RNA sequencing of aortic tissues from Prdm16 smooth muscle-specific KO and control mice
Listed in NCBI GEO
To explore the function of Prdm16 gene in vascular smooth muscle cells (VSMCs) in vivo, we generated Prdm16 SMC-specific KO mouse model using tamoxifen-inducible Myh11-CreERT2 Cre-driver.
Description
We performed bulk RNA-sequencing on aortic tissues of both Prdm16 SMC-specific KO and control mice. Differential analysis revealed ablation of Prdm16 in SMCs disrupted the global transcriptome profile of aortic tissues.
Expression of a list of genes implicated in cardiovascular disease development and SMC phenotypic modulation are significantly altered following deletion of Prdm16. We propose these transcriptome changes following loss of Prdm16 likely predispose the VSMC to a disease state.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE227nnn/GSE227692 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE227692 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA946662 ncbi.nlm.nih.gov/bioproject/PRJNA946662 ↗
project · from NCBI GEO
- PubMed 41667033 pubmed.ncbi.nlm.nih.gov/41667033 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cardiovascular disease 75% · Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE227692 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cardiovascular-disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |