Omics · study · 2026
Mitochondria in situ releasing corosolic acid enhanced antitumor effects via activating mitophagy in castration-resistant prostate cancer
Listed in NCBI GEO
Corosolic acid (CA) and its derivatives constitute a prominent class of drug candidates; however, their anticancer efficacy against resistant cancer types has been infrequently documented.
Description
Organelle-targeted drug delivery is a promising strategy to maximize anti-cancer effects and minimize adverse reactions. Herein, we report a mitochondria-targeted prodrug (CA-TPP) via an esterase-responsive phenolic ester bond to in situ release enough original drug (corosolic acid, CA) in mitochondria, and enhance the therapeutic efficacy.
This mitochondria in situ releasing original drug theragnosis significantly reduced the treatment dose of CA to 25% both in vivo and in vitro. CA-TPP induces cell death in DU145 cells through mitochondrial-apoptosis pathway. RNA sequencing analysis further revealed that CA-TPP activated apoptosis through PINK1/Parkin-mediated mitophagy.
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Inhibition of mitophagy by PINK1 shRNA resulted in an alleviation in CA-TPP induced cytotoxicity in DU145 cells. Further mechanistic study indicates that ROS production in CA-TPP-treated cells causes mitochondrial apoptosis and mitophagy. Together, this prodrug design strategy obviously improved the specificity and anti-tumor activities, which provides a novel opportunity for cancer therapeutic development and broaden the targeted therapy options.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315376 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315376 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1396617 ncbi.nlm.nih.gov/bioproject/PRJNA1396617 ↗
project · from NCBI GEO
- PubMed 41882730 pubmed.ncbi.nlm.nih.gov/41882730 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE315376 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |