Gene expression changes induced by JI051, an enhancer of platelet biogenesis, during maturation of iPSC-derived immortalized megakaryocytes

To identify factors that enhance platelet production, we performed proteomic analyses of heterogeneous imMKCL populations and identified JI051 as a small-molecule compound that promotes platelet-like particle production.

To investigate the molecular changes associated with JI051 treatment, imMKCL cells were treated with JI051 or vehicle control (DMSO) and subjected to RNA sequencing. This dataset contains gene expression profiles of JI051-treated and control imMKCL cells and provides insight into transcriptional programs associated with enhanced platelet biogenesis.