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Omics · study · 2026

Integrated Multi-Omics Analysis Links GAD1 Overexpression to Purine Metabolic Reprogramming in Lung Adenocarcinoma

Listed in NCBI GEO

RNA sequencing was performed to characterize transcriptomic changes associated with GAD1 overexpression in A549 lung adenocarcinoma cells.

Description

A549 cells transduced with GAD1-expressing lentiviral particles (adGAD1) were compared with A549 cells transduced with GFP control lentiviral particles (adGFP), with three biological replicates per group. Gene-level expression profiling was used to identify transcriptional changes and pathways associated with GAD1 overexpression.

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Expression profiling by high throughput sequencing · Homo sapiens
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Life Sciences
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RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE34578015 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title