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Data · dataset · 2015

Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats

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Age related decline in reproductive performance in women is well documented and apoptosis has been considered as one of the reasons for the decline of primordial follicle reserve.

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Recently we observed a decline in the efficiency of DNA repair ability in aged rat primordial follicles as demonstrated by decreased mRNA levels of DNA repair genes BRCA1 and H2AX . In the present study, a two-dimensional electrophoresis (2DE) proteomic approach was employed to identify differentially expressed proteins in primordial follicles isolated from ovaries of immature (∼20 days) and aged (∼400–450 days) rats.

Using MALDI-TOF/TOF MS, we identified 13 differentially expressed proteins ( p

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Biological sciences · Mathematics
Provenance · 1 source records, 13 field assertions
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DataCite10.6084/m9.figshare.156950613 d agoJSON v1
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concepts[field].local:field:life-sciencesmapping · DataCitevocabulary-mapper@1.0.0keywords['Biological Sciences']
concepts[field].local:field:mathematics-statisticsmapping · DataCitevocabulary-mapper@1.0.0keywords['Mathematics']
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