Omics · study · 2026
NeuroD1-based in situ neural regeneration for the treatment of radiation-induced brain injury
Listed in NCBI GEO
We aimed to study the therapeutic effects of in situ neural regeneration technology in radiation-induced brain injury (RIBI).
Description
We overexpressed the neural transcription factor NeuroD1 in the astrocytes of the injured area using an adeno-associated virus (AAV) in a RIBI mouse model. The therapeutic effects were compared with a RIBI mouse model treated with a control virus.
Subsequently, we explored the therapeutic effect in transcriptome through a bulk RNA sequencing.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE273nnn/GSE273938 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE273938 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1144128 ncbi.nlm.nih.gov/bioproject/PRJNA1144128 ↗
project · from NCBI GEO
- PubMed 41914076 pubmed.ncbi.nlm.nih.gov/41914076 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE273938 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |