Omics · study · 2026
High-resolution mapping of IRF4 translocations in children and adults large B-cell lymphomas [Oncoscan CNV]
Listed in NCBI GEO
Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) predominantly affects children and young adults (CAYA) presenting as localized disease with excellent prognosis.
Description
Although IRF4::IGH translocations are demonstrable in most tumors, cryptic rearrangements have been suggested. Next-generation sequencing (NGS) studies have identified a distinct mutational landscape.
Whether large B-cell lymphomas (LBCL) harboring IRF4 rearrangements in adults represent the same biological entity remains uncertain. A total of 35 pediatric and young adult (CAYA) patients diagnosed with LBCL-IRF4 (38/42 positive by fluorescence-in-situ-hybridization, FISH) and 7 adult LBCL with IRF4-R were analyzed with integrative molecular approach.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307276 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307276 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1315133 ncbi.nlm.nih.gov/bioproject/PRJNA1315133 ↗
project · from NCBI GEO
- PubMed 42466980 pubmed.ncbi.nlm.nih.gov/42466980 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome variation profiling by SNP array · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307276 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-variation-profiling-by-snp-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |