Data · dataset · 2015
Expression of imprinted genes in placenta is associated with infant neurobehavioral development
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Genomic imprinting disorders often exhibit delayed neurobehavioral development, suggesting this unique mechanism of epigenetic regulation plays a role in mental and neurological health.
Description
While major errors in imprinting have been linked to adverse health outcomes, there has been little research conducted on how moderate variability in imprinted gene expression within a population contributes to differences in neurobehavioral outcomes, particularly at birth.
Here, we profiled the expression of 108 known and putative imprinted genes in human placenta samples from 615 infants assessed by the Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scales (NNNS). Data reduction identified 10 genes ( DLX5, DHCR24, VTRNA2-1, PHLDA2, NPAP1, FAM50B, GNAS-AS1, PAX8-AS1, SHANK2 , and COPG2IT1 ) whose expression could distinguish between newborn neurobehavioral profiles derived from the NNNS.
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Clustering infants based on the expression pattern of these genes identified 2 groups of infants characterized by reduced quality of movement, increased signs of asymmetrical and non-optimal reflexes, and increased odds of demonstrating increased signs of physiologic stress and abstinence. Overall, these results suggest that common variation in placental imprinted gene expression is linked to suboptimal performance on scales of neurological functioning as well as with increased signs of physiologic stress, highlighting the central importance of the control of expression of these genes in the placenta for neurobehavioral development.
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- Repository landing page tandf.figshare.com/articles/dataset/Expression_of_imprinted_genes_in_placenta_is_… ↗
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- DOI doi.org/10.6084/m9.figshare.1491380 ↗
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Documentation and papers
- Creative Commons Attribution 4.0 International creativecommons.org/licenses/by/4.0/legalcode ↗
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- IsSupplementTo 10.1080/15592294.2015.1073880 doi.org/10.1080/15592294.2015.1073880 ↗
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- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1491380 ↗
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- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1491380 ↗
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Topics
- Stated by source
- Biological sciences · Health sciences
- From keywords
- Medicine & Health
Related
Provenance · 1 source records, 11 field assertions
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|---|---|---|---|
| DataCite | 10.6084/m9.figshare.1491380 | 12 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
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